Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat
Identifieur interne : 001078 ( Main/Exploration ); précédent : 001077; suivant : 001079Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat
Auteurs : Hantao Liu [États-Unis] ; Ida J. Llewellyn-Smith [Australie] ; Paul Pilowsky [Australie] ; Allan I. Basbaum [États-Unis]Source :
- Neuroscience Letters [ 0304-3940 ] ; 1992.
Abstract
The synaptic relationships between γ-aminobutyric acid (GABA)-immunoreactive and enkephalin-immunoreactive profiles in the cat spinal cord were examined using combined pre-embedding immunoperoxidase and post-embedding immunogold electron microscopic immunocytochemistry. Although colchicine was not used, enkephalin-immunoreactive somata and dendrites were detected in regions associated with nociceptive transmission, including laminae I, II, V and X. In each of these laminae, many GABA-immunoreactive terminals were found presynaptic to enkephalin-immunoreactive cell bodies and dendrites. We propose that disinhibition of opioid-containing neurons may be a common feature of pain-related circuits in the cat spinal cord.
Url:
DOI: 10.1016/0304-3940(92)90501-W
Affiliations:
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Although colchicine was not used, enkephalin-immunoreactive somata and dendrites were detected in regions associated with nociceptive transmission, including laminae I, II, V and X. In each of these laminae, many GABA-immunoreactive terminals were found presynaptic to enkephalin-immunoreactive cell bodies and dendrites. We propose that disinhibition of opioid-containing neurons may be a common feature of pain-related circuits in the cat spinal cord.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Liu, Hantao" sort="Liu, Hantao" uniqKey="Liu H" first="Hantao" last="Liu">Hantao Liu</name></region><name sortKey="Basbaum, Allan I" sort="Basbaum, Allan I" uniqKey="Basbaum A" first="Allan I." last="Basbaum">Allan I. 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